Bone Abstracts

Activin is a known physiologic regulator of bone metabolism. Ovariectomy-induced osteopenia has been shown to be attenuated by injection of the activin type IIA decoy receptor (ActRIIA-Fc). However, immobilization-induced osteopenia is driven by different pathways than ovariectomy-induced osteopenia, and the role of activin in immobilization-induced osteopenia has not yet been elucidated.The purpose of the study was to investigate the possible attenuatio...

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The objective of the study was to investigate whether the anti-resorptive and bone-forming dual effect of Strontium Ranelate (SrR) influences the healing of a non-critical sized femoral mid-shaft bone defect.Sixty 16-weeks-old female Wistar rats were randomized into four groups. Cylindrical defects with a diameter of 2 mm was drilled through the anterior cortex of both right and left femoral mid-shafts. Two groups were treated with SrR (900 mg/kg/day) mi...

Objective: In rodents, lactation is associated with a considerable and very rapid bone loss, which almost completely recovers after weaning. The aim of the present study was to investigate whether the bisphosphonate zoledronate (Zln) inhibits lactation induced bone loss during lactation. In addition, to study if Zln interferes with recovery of bone mass after lactation has ceased.Materials and methods: 70 NMRI mice were divided into the following groups:...

Most studies using botulinum toxin A (BTX) to achieve skeletal unloading use a study period of 3–4 weeks. The aim was to prolong this study time and to investigate the influence on the bone microstructure including the relationship between the thickness of horizontal and vertical trabeculae. Fifty-seven 16-week-old female Wistar rats were randomized into six Groups: Base; Ctrl 4w; and BTX4 4w; Ctrl 8w; BTX4 8w; BTX4+2 8w. The BTX animals were injected with 4 IU at baselin...

Objective: I.m. injections with Botox (BTX) leads to a paralysis of the muscles, resulting in a rapid loss of muscle and bone mass (disuse osteoporosis). Adipocytes and osteoblasts derive from the same mesenchymal stem cell, and commitment to one linage represses commitment to the other. Furthermore, the existence of a close communication between bone cells and endothelial cells is widely accepted.The purpose of the study was to quantify the changes in a...

Pradaxa (dabigatran etexilate) is a new anticoagulant, which recently has been approved for clinical use. Dabigatran etexilate (DE) is a direct thrombin inhibitor, which in addition to its effect on blood clotting, may have an anabolic effect on bone. Recently, it has been reported that DE could significantly reduce bone resorption and enhance bone formation resulting in a significant and substantial increase in trabecular bone mass in mice.The aim of th...

Lactation in both humans and mice is associated with a substantial bone loss, in mice this bone loss is recovered within 4 weeks after weaning. This recovery is considered to be the most rapid physiological bone formation in adult life. The aim of the study was to investigate the effect of the post-lactational anabolic response on a disuse bone loss induced by Botulinum toxin (BTX).Forty-eight NMRI mice were divided into the following groups: pregnan...

The vertebral body microstructure of young individuals appears to be divided into three equally high horizontal regions: two adjacent to the endplates and one in the centre of the vertebral body. With age this subdivision of the vertebral microstructure seems to vanish. The aim of the study was to investigate the differences in the age-related changes in vertebral microstructure in the two regions.Vertebral (L2) bone specimens from 41 women and 39 men ag...